Description

Description

Levothyroxine is a synthetic form of thyroxine (T4), an endogenous hormone, which is secreted by the thyroid and into its active metabolite L-triiodothyronine (T3) is converted. T4 and T3 bind to thyroid receptor proteins in the cell nucleus and cause metabolic effects by controlling DNA transcription and protein synthesis. Like its naturally poured counterpart, levothyroxine is a chiral connection in the L-shape.

Uses

Levothyroxine is a medication, for the treatment of underfunction of the thyroid gland (Hypothyroidism) and other conditions are used, If the production of thyroid hormones of a person is below the normal value. Levothyroxine sodium replaces or provides support from thyroid hormones, which are normally produced by the thyroid gland. Low thyroid hormone levels can of course occur or if the thyroid gland has been violated by radiation/medication or removed by surgery. Levothyroxine is also known as L-thyroxine or T4.

Improved metabolism

The normalization of the thyroid function helps levothyroxine sodium, to maintain a healthy metabolism, What effective fat loss- and muscle building phases is decisive. Increased energy level A proper thyroid function can lead to better energy levels, which means that you have the endurance and resilience for intensive training units.

Improved muscle regeneration

Balanced thyroid hormones can support protein synthesis and muscle repair, Which is decisive for bodybuilders in their recovery phase.

Weight management

By regulating the metabolism, this drug helps, to keep a healthy weight, A key factor in bodybuilding for both aesthetic and performance goals. Constant performance Stable thyroid values ​​ensure a constant physical and mental performance, Crucial for athletes, who have to maintain a high level of training intensity.

Use with growth hormone

Patient, The human growth hormone (HGH) receive, Should take T4, To prevent a lack of this hormone, Since growth hormone significantly increases the conversion from T4 to T3, Which can lead to a pathological T4 deficiency.

Dosage and administration

It is recommended, Taking levothyroxine on an empty stomach about half an hour to an hour before meals, To maximize the recording. It is also recommended, Taking the tablet with a glass of water, To make it easier to swallow and dissolve the tablet for recording. The doses vary depending on the age group and the individual condition of the patient, Body weight and compliance with the medication and diet. The maximum dosage can 300-400 reach McG per day, But that's rare. Most people have to be careful, to start with a low dosage and consult a doctor, To determine the optimal dose.

How to use it

Basically, the dosage begins with 25-50 McG per day and increases all 5-6 days over 25-50 mcg pro Tag. And the maximum is included 300-400 mcg pro Tag. Spread a few tablets throughout the day. The maximum cycle lasts seven weeks. At least six weeks should be between the cycles. In addition, your thyroid will work normally again. It is often stacked with Clenbutos, To make both even more effective in fat loss.

• Average dose: 100 bis 200 mcg pro Tag
• Effective dosage: Pyramid system of proven cycle: 5-6 weeks

Pharmaceuticalokinetics

The absorption of orally administered levothyroxine ranges from 40 bis 80%, The majority of the drug from the jejunum and upper ileum are recorded. Levothyroxine intake is increased by fasting and in certain syndromes, reduced by certain foods and with increasing age.

The half -life is 6–7 days in people with normal laboratory values; 9–10 days in people with hypothyroidism; 3–4 days in people with hyperthyroidism. Thyroid hormones are mainly through the kidneys (approximately 80%) eliminated, whereby the urea excretion decreases with age. The remaining 20% from T4 are excreted in the chair.

Bonds

• Regulates your metabolism
• Burned fat
• Increases anabolic processes and muscle growth
• Stimulation of the central nervous system

Side effects

Allergies against the drug are unlikely, But when the patient develops a difficult reaction to this medication, Like breathing difficulties, Shortness of breath or swelling on the face and the tongue, it is absolutely necessary, that the patient is immediately looking for medical help. Side effects are generally caused by incorrect dosage. Side effects of excessive doses are weight loss, Difficulties, To endure heat, Sweat, Anxiety, insomnia, Tremble and faster heartbeat. The application is in humans, who recently had a heart attack, not recommended. The application during pregnancy is considered safe. Acute overdose can be fever, Hypoglycemia, Heart failure, Coma and not recognized adrenal insufficiency cause. Acute massive overdose can be life -threatening; The treatment should be symptomatic and supportive. Massive overdose can require beta blockers, To treat the increased sympathomimetic activity. The side effects of an overdose occur 6 Hours up to 11 Days after taking.

• Chest pain, Discomfort or tightness
• Swallowing
• Extreme fatigue
• Fainting
• Faster, slower, irregular, violent or frenzied heartbeat or pulse
• In scope
• nausea
• Sweat
• Tremble

Profile

• Half-life: 6-24 Hours
• Frequency of intake: 1-2 times a day

Precautionary measures

Longer use of high doses can lead to serious problems with the thyroid system and to suppress endogenous hormone production. Studies show up to 20%reduction in endogenous production 3 Weekly use. However, if it is used correctly in the recommended doses, the thyroid function is recovering 3-4 weeks. Levothyroxine has adrenaline -like effects, including increased heart rate and nervousness, that could be avoided by using beta blockers.

Contraindications

Levothyroxine is contraindicated in people with hypersensitivity to levothyroxine sodium or some component of the wording, People with acute myocardial infarction and people with thyroid oxicosis of all etiology. Levothyroxine is also contraindicated in people with non -corrected adrenal insufficiency, Since thyroid hormones can cause an acute adrenal crisis, By increasing the metabolic clearance of glucocorticoids.

Interactions with other medication

There are also food and other substances, that can interfere with the intake of thyroxine replacement. Avoid taking calcium- and iron preparations within 4 Hours after taking the medication and avoid taking soy products within 3 Hours after taking the medication, Since these can reduce the intake of the drug. Other substances, that reduce the recording, Are aluminum- and magnesium -containing antacids, Simethicon oder Sucralfat, Cholestyramin, Colestipol, question.

Other substances cause other serious side effects. Ketamine can cause high blood pressure and tachycardia and trallyyclic and tetracyclic antidepressants increase its toxicity. On the other hand, lithium causes hyperthyroidism, by influencing the iodine metabolism of the thyroid gland itself and thus also inhibits the synthetic levothyroxine.

Special warnings

Levothyroxine sodium should be over in patients 50 Years and long -lasting hypothyroidism are introduced very slowly, To avoid sudden increases in metabolic requirements. Patients with pan -hypopitualism or other causes, which predispose to adrenal insufficiency, can react to treatment with levothyroxine, And it is recommended, Before the administration of levothyroxine, corticosteroid therapy. Levothyroxine sodium should be in patients with cardiovascular diseases, including angina, coronary heart disease, High blood pressure and in older people, which are more likely to have an occult heart disease, be used with caution.

Contraindicated in patients with untreated subclinar (suppressed TSH level with normal T3- and T4 levels) Manifest thyreotoxicosis of all etiology and in patients with acute myocardial infarction. The thyroid replacement therapy can increase the insulin- or other antidiabetic therapy (Like metformin) Cause dose requirements. Caution is advised in patients with diabetes mellitus and diabetes insipidus. Subclinical hyperthyroidism can be associated with bone loss. To minimize the risk of osteoporosis, Should the dose of levothyroxine sodium be titrated to the lowest possible effective level.

storage

• Keep away from children
• In a cool, dry place, Store away from direct sunlight
• Store at room temperature
• Do not use after the expiry date