Description

SARTANOS 20 MG DRIADA MEDICAL (TELMISARTAN) DESCRIPTION

Telmisartan is a means of blood pressure, an angiotensin II receptor antagonist (Typ AT1). It has a very high affinity for this receptor subtype. Telmisartan displaces angiotensin II from binding to AT1 receptors. An affinity for other subtypes of AT receptors was not found. The functional significance of other receptor subtypes and the effect of increased angiotensin II levels (As a result of taking Telmisartan) is not known to them.

Das Renin-Angiotensin-aldosterone-System (RAAS) is responsible for regulating blood pressure and fluid budget. It regulates its reaction to things like Angiotensin, A naturally occurring chemical, which can narrow their blood vessels and increase blood pressure. A certain type of angiotensin - specifically angiotensin 2 - is important for us here, Since the use of anabolic steroids increases the mirror of this specific type of hormone.

Telmisartan lowers the plasma balance level, However, plasma-renin does not inhibit, Do not block ion channels and do not inhibit ACE (Kinase II), that also destroys bradykinine. Therefore, there are no side effects associated with Bradykinin.

The blockade of the Renin Angiotensin system with ACE inhibitors, which inhibit the biosynthesis of angiotensin II from angiotensin i, is often used in the treatment of high blood pressure. ACE inhibitor also inhibit the breakdown of Bradykinin, a reaction, which is also catalyzed by ACE. Also acetan ace (Kininase I) not inhibited, has no influence on the reaction to Bradykinin. Whether this difference has clinical relevance, is not yet known. Telmisartan does not bind to other hormone receptors or ion channels, of which is known, that they are important for cardiovascular regulation, and do not block them either. The blockade of the angiotensin-II receptor inhibits the negative regulatory feedback from Angiotesin II to Renins secretion, But the resulting increased plasma-renin activity and the circulating angiotensin II levels do not raise the effect of Telmisartan on blood pressure.

Use for Sartanos 20 mg Driada Medical (Telmisartan)

Telmisartan reduces left ventricular hypertrophy (LVH) and reduces the visceral fat. This should be of particular interest to athletes. LVH is an adaptive reaction to intensive strength training, whose effect is reinforced by the use of steroids. LVH is generally harmless among highly trained athletes, However, it goes hand in hand with a reduced heart function, Especially at the age of the athlete. A reduction in the visceral fat is also accompanied by a lower cardiovascular risk. The use of Telmisartan is a scientifically proven damage to the damage reduction, which lowers the overall mortality and in particular the risk of cardiovascular diseases.

Pharmacokinetics Telmisartan

When taking oral intake, it is quickly absorbed from the gastrointestinal tract. The bioavailability is 50 %. If you take food at the same time, the AUC is accepted between 6 % (With a dose of 40 mg) and 19 % (With a dose of 160 mg). 3 Hours after taking the plasma concentration levels off, independently of, whether the intake is taken with a meal or on an empty stomach. Communication with plasma proteins is 99.5 %. The average values ​​of the apparent VD in the equilibrium stage

are 500 l. Metabolized by conjugation with glucuronic acid. Metabolites are pharmacologically inactive. T1/2 - more than 20 Hours. Is excreted unchanged over the intestine. The cumulative excretion through the kidneys is less than 1 %. Gesamtplasmaclearance – 1000 Ml/min (renal blood flow - 1500 Ml/min).

How is Sartanos 20 mg Driada Medical (Telmisartan) to apply?

For adults, the daily dose is 20-40 mg (1 Times/day). In some patients, the blood pressure -lowering effect can already be used with a dose of 20 Mg/day can be reached. If necessary, the dose can be 80 Mg/day can be increased.

In patients with restricted kidney function and in older patients, no dose adjustment is required.

For patients with limited liver function, the recommended daily dose is 40 mg.

The doses for athletes are the same - the use of a daily dosage of 20 bis 40 mg once a day, To the risk of arteriosclerosis, Cardiovascular diseases and/or strokes to reduce bodybuilders using steroids with curve. This can also be improved by HDL cholesterol, insulin sensitivity, The mitochondrial activity, lead to the endothelial function and cognitive function.

positive effects

• Arterial hypertension
• Reduce the cardiovascular risk
• Improvements in HDL cholesterol
• Insulin sensitivity
• Increase mitochondrial activity
• Endothelial function
• Cognitive function.
• Reduces the left ventricular hypertrophy (LVH)
• Reduced visceral fat
• Reduces water retention
• Reduces adrenaline production, which causes a vasoconstriction of the blood vessels

Sartanos side effects 20 mg Driada Medical (Telmisartan)

• Side effects of Telmisartan are rare and can include the following:
• Changes in the view
• dizziness, Dashtiness or fainting
• Quick heartbeat
• Big beehives
• Pain when urinating or changes in the urge to urinate
• Swelling on hands, Lower legs and feet

Steroidprofil

• Half-life: 24 Hours
• Frequency of intake: 1-2 times a day

Contraindications for steroids

• Negative pressure
• pregnancy
• When pregnancy is determined, Should telmisartan tablets be discontinued as soon as possible.

How is Telmisartan to be kept?

• Keep away from children
• In a cool place, Store in a dry place out of direct sunlight
• At 25 °C (77 °F) to store; Excursions allowed up to 15 ° -30 ° C (59°-86°F)
• Do not use after the expiry date